Global Phylogeny of Mycobacterium avium and Identification of Mutation Hotspots During Niche Adaptation.

ABSTRACT: Mycobacterium avium is separated into four subspecies: M. avium subspecies avium (MAA), M. avium subspecies silvaticum (MAS), M. avium subspecies hominissuis (MAH), and M. avium subspecies paratuberculosis (MAP). Understanding the mechanisms of host and tissue adaptation leading to their clinical significance is vital to reduce the economic, welfare, and public health concerns associated with diseases they may cause in humans and animals. Despite substantial phenotypic diversity, the subspecies nomenclature is controversial due to high genetic similarity. Consequently, a set of 1,230 M. avium genomes was used to generate a phylogeny, investigate SNP hotspots, and identify subspecies-specific genes. Phylogeny reiterated t

SUBMITTER: Mizzi R 

PROVIDER: S-EPMC9121174 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature