Comparison of Amitriptyline and US Food and Drug Administration-Approved Treatments for Fibromyalgia: A Systematic Review and Network Meta-analysis.

ABSTRACT:

Importance

Amitriptyline is an established medication used off-label for the treatment of fibromyalgia, but pregabalin, duloxetine, and milnacipran are the only pharmacological agents approved by the US Food and Drug Administration (FDA) to treat fibromyalgia.

Objective

To investigate the comparative effectiveness and acceptability associated with pharmacological treatment options for fibromyalgia.

Data sources

Searches of PubMed/MEDLINE, Cochrane Library, Embase, and Clinicaltrials.gov were conducted on November 20, 2018, and updated on July 29, 2020.

Study selection

Randomized clinical trials (RCTs) comparing amitriptyline or any FDA-approved doses of investigated drugs.

Data extraction and synthesis

This study follows the Preferred Reporting Items for

SUBMITTER: Farag HM 

PROVIDER: S-EPMC9121190 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature