Curcumin as an effective suppressor of miRNA expression in patients with knee osteoarthritis.

ABSTRACT:

Objective

Osteoarthritis is the most common disease in the group of joint diseases, and its incidence is directly related to aging. Given the anti-inflammatory effects of curcumin as an active ingredient of turmeric, we aimed to investigate the effects of this compound in a new curcumin nanomicelle formula named SinaCurcumin^® on the expression of microRNAs (miRNAs) involved in immune responses of patients with osteoarthritis.

Materials and methods

We divided 30 patients with osteoarthritis into two groups namely, nano curcumin-receiving (15 patients) and placebo-receiving (15 patients) and we studied them for 3 months. The Iranian Registry of Clinical Trials (IRCT) approved our study with the IRCT registry No. IRCT20151028024760N4. We evaluated the rates of the ex

SUBMITTER: Atabaki M 

PROVIDER: S-EPMC9121260 | biostudies-literature | 2022 Jul-Aug

REPOSITORIES: biostudies-literature