Association of 5α-Reductase Inhibitors With Prostate Cancer Mortality.

ABSTRACT:

Importance

There is evidence that 5α-reductase inhibitors (5-ARIs), a standard treatment of benign prostate hyperplasia, are associated with a decrease in the incidence of prostate cancer (PCa). However, studies to date have had conflicting results regarding the association with prostate cancer mortality (PCM).

Objective

To evaluate the association of treatment with 5-ARIs with PCM in men without a prior diagnosis of PCa.

Design, setting, and participants

This population-based cohort study was conducted in Stockholm, Sweden, between January 1, 2007, and December 31, 2018, and included 429 977 men with a prostate-specific antigen (PSA) test within the study period. Study entry was set to 1 year after the first PSA test. Data were analyzed from September 2021 to Decembe

SUBMITTER: Bjornebo L 

PROVIDER: S-EPMC9121300 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature