Autoimmune Disease in Patients With Advanced Thymic Epithelial Tumors.

ABSTRACT:

Introduction

Paraneoplastic autoimmune diseases (ADs) are a hallmark of thymic epithelial tumors (TETs) and affect treatment management in patients with advanced-stage tumors, yet the risk factors for development of AD in advanced TET remain poorly understood.

Methods

All patients with advanced TET treated at Stanford University between 2006 and 2020 were included. Charts were retrospectively reviewed for the presence of AD, demographic information, and treatment history. Next-generation sequencing was performed on available TET tissue. Multivariate regression was used to evaluate variables associated with AD.

Results

A total of 48 patients were included in the analysis with a median follow-up of 5.4 years. One-third (n = 16, 33%) were diagnosed with having ADs, with

SUBMITTER: Singhal S 

PROVIDER: S-EPMC9121321 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature