Glutamine restores mitochondrial respiration in bleomycin-injured epithelial cells.

ABSTRACT: Whether from known or unknown causes, loss of epithelial repair plays a central role in the pathogenesis of pulmonary fibrosis. Recently, diminished mitochondrial function has been implicated as a factor contributing to the loss of epithelial repair but the mechanisms mediating these changes have not been defined. Here, we investigated the factors contributing to mitochondrial respiratory dysfunction after bleomycin, a widely accepted agent for modeling pulmonary fibrosis in mice and in vitro systems. In agreement with previous reports, we found that mitochondrial respiration was decreased in lung epithelial cells exposed to bleomycin, but also observed that responses differed depending on the type of metabolic fuel available to cells. For example, we found that mitochondrial respiration w

SUBMITTER: Shaghaghi H 

PROVIDER: S-EPMC9121335 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature