Design, Synthesis, and Preliminary Evaluation of [⁶⁸Ga]Ga-NOTA-Insulin as a PET Probe in an Alzheimer's Disease Mouse Model.

ABSTRACT: Aberrant insulin signaling has been considered one of the risk factors for the development of Alzheimer's disease (AD) and has drawn considerable attention from the research community to further study its role in AD pathophysiology. Herein, we describe the development of an insulin-based novel positron emission tomography (PET) probe, [⁶⁸Ga]Ga-NOTA-insulin, to noninvasively study the role of insulin in AD. The developed PET probe [⁶⁸Ga]Ga-NOTA-insulin showed a significantly higher uptake (0.396 ± 0.055 SUV) in the AD mouse brain compared to the normal (0.140 ± 0.027 SUV) mouse brain at 5 min post injection and also showed a similar trend at 10, 15, and 20 min post injection. In addition, [⁶⁸Ga]Ga-NOTA-insulin was found to have a differential uptake in vario

SUBMITTER: Taubel JC 

PROVIDER: S-EPMC9121347 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature