Real-Time High-Sensitivity Reaction Monitoring of Important Nitrogen-Cycle Synthons by ¹⁵N Hyperpolarized Nuclear Magnetic Resonance.

ABSTRACT: Here, we show how signal amplification by reversible exchange hyperpolarization of a range of ¹⁵N-containing synthons can be used to enable studies of their reactivity by ¹⁵N nuclear magnetic resonance (NO₂^- (28% polarization), ND₃ (3%), PhCH₂NH₂ (5%), NaN₃ (3%), and NO₃^- (0.1%)). A range of iridium-based spin-polarization transfer catalysts are used, which for NO₂^- work optimally as an amino-derived carbene-containing complex with a DMAP-d₂ coligand. We harness long ¹⁵N spin-order lifetimes to probe in situ reactivity out to 3 × T₁. In the case of NO₂^- (T₁ 17.7 s at 9.4 T),

SUBMITTER: Rayner PJ 

PROVIDER: S-EPMC9121385 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature