Intrinsic mechanisms stabilize encoding and retrieval circuits differentially in a hippocampal network model.

ABSTRACT: Acetylcholine regulates memory encoding and retrieval by inducing the hippocampus to switch between pattern separation and pattern completion modes. However, both processes can introduce significant variations in the level of network activity and potentially cause a seizure-like spread of excitation. Thus, mechanisms that keep network excitation within certain bounds are necessary to prevent such instability. We developed a biologically realistic computational model of the hippocampus to investigate potential intrinsic mechanisms that might stabilize the network dynamics during encoding and retrieval. The model was developed by matching experimental data, including neuronal behavior, synaptic current dynamics, network spatial connectivity patterns, and short-term synaptic plasticity. Furth

SUBMITTER: Hummos A 

PROVIDER: S-EPMC9121438 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature