Changes in the gut microbiome associated with liver stiffness improvement in nonalcoholic steatohepatitis.

ABSTRACT:

Background

Longitudinal studies are needed to decipher mechanistic links between the gut microbiome and nonalcoholic steatohepatitis (NASH). We examined shifts in the gut microbiome in persons with NASH with improvement in liver stiffness measurement (LSM) by magnetic resonance (MR) elastography.

Methods

Gut microbial profiling was performed at baseline and study completion (24 weeks) using 16 S rRNA gene sequencing in 69 adults with biopsy-confirmed NASH and significant fibrosis (stages 2-3) enrolled in a multi-center randomized controlled trial evaluating selonsertib alone or in combination with simtuzumab. Differential abundance of bacterial taxa at baseline and end of study were examined in participants with and without longitudinal improvement in LSM. Gut microbial shif

SUBMITTER: Sharpton SR 

PROVIDER: S-EPMC9121469 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature