Neural Response to Social Exclusion Moderates the Link Between Adolescent Anxiety Symptoms and Substance Use.

ABSTRACT:

Background

Substance use (SU) typically increases from middle to late adolescence. Anxiety is one factor associated with greater SU, although variability in who uses substances remains. Some models suggest that brain-based susceptibility markers could reveal which adolescents are at a higher risk for psychopathology, but it is unknown whether these individual differences attenuate or accentuate the association between anxiety and elevated SU even if normative. This study addressed this gap by testing whether neural response to social exclusion moderates the association between anxiety symptoms and increased SU from middle to late adolescence.

Methods

Participants were 181 Mexican-origin adolescents (48% female; 16-17 years old) who completed a social exclusion task during a

SUBMITTER: Beard SJ 

PROVIDER: S-EPMC9121759 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature