Potential Utility of Systemic Plasma Biomarkers for Evaluation of Pediatric Schistosomiasis in Western Kenya.

ABSTRACT:

Introduction

Current diagnostic tools for schistosomiasis are limited, and new tests are necessary to enhance disease diagnosis and surveillance. Identification of novel disease-specific biomarkers may facilitate the development of such tests. We evaluated a panel of biomarkers used in sepsis and parasitic diseases for their potential suitability in the diagnosis of schistosomiasis.

Objective

The study evaluated the levels of systemic plasma biomarkers in relation to Schistosoma mansoni infection and parasite burden.

Methods

Six biomarkers were measured in the plasma of children from schistosomiasis-endemic regions using ELISA. The concentration of soluble CD23 (sCD23) and lipopolysaccharide (LPS) was tested in 199 and 124 plasma samples, respectively, while in

SUBMITTER: Ondigo BN 

PROVIDER: S-EPMC9121796 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature