TFR1 expression in induced sputum is associated with asthma severity.

ABSTRACT:

Background

Asthma is characterized as a chronic inflammatory airway disease. Iron accumulation is related to asthma pathogenesis. Transferrin receptor 1(TFR1) expression is associated with intracellular iron overload in macrophages. In our study, we explored the association among TFR1 expression, the inflammatory macrophage phenotype, and asthma severity.

Methods

Induced sputum was collected from 50 asthma patients. Real-time PCR was used to evaluate mRNA expression. The status of inflammatory macrophage phenotype was assessed using flow cytometry.

Results

TFR1 levels were inversely correlated with forced expiratory volume in 1 s (FEV₁)/forced vital capacity (FVC) and FEV₁/vital capacity (VC). Among inflammatory cytokines, TFR1 expression was pos

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9121881 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature