Diabetes, cigarette smoking and transcription factor 7-like 2 (Tcf7L2) in the UK Biobank cohort.

ABSTRACT:

Background —

Smokers are 30 to 40 percent more likely to develop type 2 diabetes than non-smokers. A type 2 diabetes gene, Tcf7L2, which had lost activity, caused rats to consume more nicotine. In the present study, we used data from the UK Biobank to examine the relationship of smoking, type 2 diabetes, and Tcf7L2 in human subjects.

Methods —

The Tcf7L2 gene has two SNPs, rs7903146 and rs4506565, reported to be associated with type 2 diabetes. They have approximately equal power to estimate risk for type 2 diabetes, and the results from one correlate 92% with the other. We examined the genotypes of these SNPs and cigarette consumption.

Results —

Genotype TT, linked to type 2 diabetes, smoked the least. But because of the large sample size (approximately 111,00

SUBMITTER: Lehrer S 

PROVIDER: S-EPMC9121894 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature