Identification and Validation of Immune Molecular Subtypes and Immune Landscape Based on Colon Cancer Cohort.

ABSTRACT:

Background

The incidence and mortality rates of colon adenocarcinoma (COAD), which is the fourth most diagnosed cancer worldwide, are high. A subset of patients with COAD has shown promising responses to immunotherapy. However, the percentage of patients with COAD benefiting from immunotherapy is unclear. Therefore, gaining a better understanding of the immune milieu of colon cancer could aid in the development of immunotherapy and suitable combination strategies.

Methods

In this study, gene expression profiles and clinical follow-up data were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, and molecular subtypes were identified using the ConsensusClusterPlus package in R. Univariate and multivariate Cox regression analyses

SUBMITTER: Qi W 

PROVIDER: S-EPMC9121983 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature