Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium.

ABSTRACT:

Background

Both elevated and low resting heart rates are associated with atrial fibrillation (AF), suggesting a U-shaped relationship. However, evidence for a U-shaped causal association between genetically-determined resting heart rate and incident AF is limited. We investigated potential directional changes of the causal association between genetically-determined resting heart rate and incident AF.

Method and results

Seven cohorts of the AFGen consortium contributed data to this meta-analysis. All participants were of European ancestry with known AF status, genotype information, and a heart rate measurement from a baseline electrocardiogram (ECG). Three strata of instrumental variable-free resting heart rate were used to assess possible non-linear associations between gene

SUBMITTER: Siland JE 

PROVIDER: S-EPMC9122202 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature