Influenza A virus NS1 protein hijacks YAP/TAZ to suppress TLR3-mediated innate immune response.

ABSTRACT: The Hippo signaling pathway, which is historically considered as a dominator of organ development and homeostasis has recently been implicated as an immune regulator. However, its role in host defense against influenza A virus (IAV) has not been widely investigated. Here, we found that IAV could activate the Hippo effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) through physical binding of the IAV non-structural protein 1 (NS1) with C-terminal domain of YAP/TAZ, facilitating their nuclear location. Meanwhile, YAP/TAZ downregulated the expression of pro-inflammatory and anti-viral cytokines against IAV infection, therefore benefiting virus replication and host cell apoptosis. A mouse model of IAV infection further demonstrated Yap deficienc

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC9122210 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature