Insights into Mus musculus Population Structure across Eurasia Revealed by Whole-Genome Analysis.

ABSTRACT: For more than 100 years, house mice (Mus musculus) have been used as a key animal model in biomedical research. House mice are genetically diverse, yet their genetic background at the global level has not been fully understood. Previous studies have suggested that they originated in South Asia and diverged into three major subspecies, almost simultaneously, approximately 110,000-500,000 years ago; however, they have spread across the world with the migration of modern humans in prehistoric and historic times (∼10,000 years ago to the present day) and have undergone secondary contact, which has complicated the genetic landscape of wild house mice. In this study, we sequenced the whole-genome sequences of 98 wild house mice collected from Eurasia, particularly East Asia, Southeast Asia, and

SUBMITTER: Fujiwara K 

PROVIDER: S-EPMC9122283 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature