COVID-19 vaccine booster dose needed to achieve Omicron-specific neutralisation in nursing home residents.

ABSTRACT:

Background

Nursing home (NH) residents have borne a disproportionate share of SARS-CoV-2 morbidity and mortality. Vaccines have limited hospitalisation and death from earlier variants in this vulnerable population. With the rise of Omicron and future variants, it is vital to sustain and broaden vaccine-induced protection. We examined the effect of boosting with BNT162b2 mRNA vaccine on humoral immunity and Omicron-specific neutralising activity among NH residents and healthcare workers (HCWs).

Methods

We longitudinally enrolled 85 NH residents (median age 77) and 48 HCWs (median age 51), and sampled them after the initial vaccination series; and just before and 2 weeks after booster vaccination. Anti-spike, anti-receptor binding domain (RBD) and neutralisation titres to the

SUBMITTER: Canaday DH 

PROVIDER: S-EPMC9122310 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature