Repertoires of SARS-CoV-2 epitopes targeted by antibodies vary according to severity of COVID-19.

ABSTRACT: Antibodies to SARS-CoV-2 are central to recovery and immunity from COVID-19. However, the relationship between disease severity and the repertoire of antibodies against specific SARS-CoV-2 epitopes an individual develops following exposure remains incompletely understood. Here, we studied seroprevalence of antibodies to specific SARS-CoV-2 and other betacoronavirus antigens in a well-annotated, community sample of convalescent and never-infected individuals obtained in August 2020. One hundred and twenty-four participants were classified into five groups: previously exposed but without evidence of infection, having no known exposure or evidence of infection, seroconverted without symptoms, previously diagnosed with symptomatic COVID-19, and recovered after hospitalization with COVID-19. Pr

SUBMITTER: Gregory DJ 

PROVIDER: S-EPMC9122311 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature