The role of the mucin-glycan foraging <i>Ruminococcus gnavus</i> in the communication between the gut and the brain.

ABSTRACT: Ruminococcus gnavus is a prevalent member of the human gut microbiota, which is over-represented in inflammatory bowel disease and neurological disorders. We previously showed that the ability of R. gnavus to forage on mucins is strain-dependent and associated with sialic acid metabolism. Here, we showed that mice monocolonized with R. gnavus ATCC 29149 (Rg-mice) display changes in major sialic acid derivatives in their cecum content, blood, and brain, which is accompanied by a significant decrease in the percentage of sialylated residues in intestinal mucins relative to germ-free (GF) mice. Changes in metabolites associated with brain function such as tryptamine, indolacetate, and trimethylamine N-oxide were also detected in the cecal content of Rg

SUBMITTER: Coletto E 

PROVIDER: S-EPMC9122312 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature