The disposition of trimethoprim and sulfadiazine in neonatal foals after intravenous administration.

ABSTRACT:

Background

Septicaemia in the neonatal foal is caused by both Gram positive and Gram negative bacteria. The life-threatening nature of this condition requires treatment to be initiated with broad spectrum antimicrobial drugs pending antimicrobial susceptibility testing. Potentiated sulphonamides, for example, trimethoprim combined with sulfadiazine, could be clinically relevant options but their pharmacokinetics in the neonatal foal are unknown.

Objectives

To describe the plasma disposition of trimethoprim and sulfadiazine in neonatal foals and to relate the results to patterns in the minimum inhibitory concentration (MIC) for Escherichia coli, a recognized pathogen in neonatal foal sepsis.

Method

A total of five doses of trimethoprim (2.5 mg/kg) and sulfadiazine (12.

SUBMITTER: Ekstrand C 

PROVIDER: S-EPMC9122441 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature