Epistatic selection on a selfish Segregation Distorter supergene - drive, recombination, and genetic load.

ABSTRACT: Meiotic drive supergenes are complexes of alleles at linked loci that together subvert Mendelian segregation resulting in preferential transmission. In males, the most common mechanism of drive involves the disruption of sperm bearing one of a pair of alternative alleles. While at least two loci are important for male drive-the driver and the target-linked modifiers can enhance drive, creating selection pressure to suppress recombination. In this work, we investigate the evolution and genomic consequences of an autosomal, multilocus, male meiotic drive system, Segregation Distorter (SD) in the fruit fly, Drosophila melanogaster. In African populations, the predominant SD chromosome variant, SD-Mal, is characterized by two overlapping, paracentric inversio

SUBMITTER: Navarro-Dominguez B 

PROVIDER: S-EPMC9122502 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature