Changes in synaptic density in the subacute phase after ischemic stroke: A ¹¹C-UCB-J PET/MR study.

ABSTRACT: Functional alterations after ischemic stroke have been described with Magnetic Resonance Imaging (MRI) and perfusion Positron Emission Tomography (PET), but no data on in vivo synaptic changes exist. Recently, imaging of synaptic density became available by targeting synaptic vesicle protein 2 A, a protein ubiquitously expressed in all presynaptic nerve terminals. We hypothesized that in subacute ischemic stroke loss of synaptic density can be evaluated with ¹¹C-UCB-J PET in the ischemic tissue and that alterations in synaptic density can be present in brain regions beyond the ischemic core. We recruited ischemic stroke patients to undergo ¹¹C-UCB-J PET/MR imaging 21 ± 8 days after stroke onset to investigate regional ¹¹C-UCB-J SUVR (standardized upt

SUBMITTER: Michiels L 

PROVIDER: S-EPMC9122519 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature