Pan-cancer assessment of mutational landscape in intrinsically disordered hotspots reveals potential driver genes.

ABSTRACT: Large-scale cancer genome sequencing has enabled the catalogs of somatic mutations; however, the mutational impact on intrinsically disordered protein regions (IDRs) has not been systematically investigated to date. Here, we comprehensively characterized the mutational landscapes of IDRs and found that IDRs have higher mutation frequencies across diverse cancers. We thus developed a computational method, ROI-Driver, to identify putative driver genes enriching IDR and domain hotspots in cancer. Numerous well-known cancer-related oncogenes or tumor suppressors that play important roles in cancer signaling regulation, development and immune response were identified at a higher resolution. In particular, the incorporation of IDR structures helps in the identification of novel potential driver

SUBMITTER: Zou H 

PROVIDER: S-EPMC9122534 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature