Docking and in vitro molecular biology studies of p-anisidine-appended 1-hydroxy-2-acetonapthanone Schiff base lanthanum(iii) complexes.

ABSTRACT: A new series of lanthanum(iii) complexes was synthesized using a p-anisidine-appended 1-hydroxy-2-acetonapthanone (3) Schiff base and characterized via spectroscopic methods. The ligand was synthesized via sonication and the crystalline product was characterized using X-ray crystallography. The genotoxicity of the compound was assessed primarily by the bacterial reverse mutation (Ames) test and the in vitro mammalian chromosome aberration test; in both cases, the samarium complex 5 was found to be non-mutagenic. The anti-tumor activity of complexes 4, 5, and 6 was assayed against HeLa tumor cells and screened using the MTT assay. The IC₅₀ value of complex 5 was found to be 34 ± 1.2 μg mL^-1 and this compound exhibited superior activity towar

SUBMITTER: Sathiyanarayanan V 

PROVIDER: S-EPMC9122577 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature