Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale.

ABSTRACT: The novel Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is a potential factor for fatal illness and a tremendous concern for global public health. The COVID-19 pandemic has entered a dangerous new phase. In the context of drug discovery, the structurally-unique and chemically-diverse natural products have been valuable sources for drug leads. In this review, we report for potential candidates derived from natural sources with well-reported in vitro efficacy against SARS-CoV during the last decade. Additionally, a library of 496 phenolic metabolites was subjected to a computer-aided virtual screening against the active site of the recently reported SARS-CoV Main protease (M^pro). Analysis of physicochemical properties of these natural products has been carried ou

SUBMITTER: Sayed AM 

PROVIDER: S-EPMC9122629 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature