A N⁷-Methylguanine-Related Gene Signature Applicable for the Prognosis and Microenvironment of Prostate Cancer.

ABSTRACT:

Background

Despite the constant iteration of small-molecule inhibitors and immune checkpoint inhibitors, PRAD (prostate adenocarcinoma) patients with distant metastases and biochemical recurrence maintain a poor survival outcome along with an increasing morbidity in recent years. N⁷-Methylguanine, a new-found type of RNA modification, has demonstrated an essential role in tumor progression but has hardly been studied for its effect on prostate carcinoma. The current study aimed to seek m⁷G (N7-methylguanosine) related prognostic biomarkers and potential targets for PRAD treatment.

Methods

42 genes related to m⁷G were collected from former literatures and GSEA (Gene Set Enrichment Analysis) website. Then, RNA-seq (RNA sequencing) and clinical

SUBMITTER: Mei W 

PROVIDER: S-EPMC9122703 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature