Identification and quantification of immune infiltration landscape on therapy and prognosis in left- and right-sided colon cancer.

ABSTRACT:

Background

The left-sided and right-sided colon cancer (LCCs and RCCs, respectively) have unique molecular features and clinical heterogeneity. This study aimed to identify the characteristics of immune cell infiltration (ICI) subtypes for evaluating prognosis and therapeutic benefits.

Methods

The independent gene datasets, corresponding somatic mutation and clinical information were collected from The Cancer Genome Atlas and Gene Expression Omnibus. The ICI contents were evaluated by "ESTIMATE" and "CIBERSORT." We performed two computational algorithms to identify the ICI landscape related to prognosis and found the unique infiltration characteristics. Next, principal component analysis was conducted to construct ICI score based on three ICI patterns. We analyzed the correl

SUBMITTER: Guo JN 

PROVIDER: S-EPMC9122887 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature