Type I IFN stimulates IFI16-mediated aromatase expression in adipocytes that promotes E₂-dependent growth of ER-positive breast cancer.

ABSTRACT: Although type I interferons (IFNs) play multifaceted roles during tumorigenesis and cancer treatment, the interplay between type I IFNs and estrogen signaling in breast cancer (BC) microenvironment is not well understood. Here, we report a novel function of type I IFNs in inducing aromatase expression in adipose tissues surrounding BC, which potentiates the E₂-dependent growth of estrogen receptor (ER)-positive BC. First, we found that expression levels of type I IFNs correlate negatively with clinical outcome but positively with tumor grade in patients with ER-positive BC. Levels of type I IFNs were elevated in cocultured media of immune cells and BC cells, which increased aromatase expression and E₂ production in Simpson-Golabi-Behmel syndrome preadipocytes. The typ

SUBMITTER: Ka NL 

PROVIDER: S-EPMC9122892 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature