Memory, switches, and an OR-port through bistability in chemically fueled crystals.

ABSTRACT: The ability to store information in chemical reaction networks is essential for the complex behavior we associate with life. In biology, cellular memory is regulated through transcriptional states that are bistable, i.e., a state that can either be on or off and can be flipped from one to another through a transient signal. Such memory circuits have been realized synthetically through the rewiring of genetic systems in vivo or through the rational design of reaction networks based on DNA and highly evolved enzymes in vitro. Completely bottom-up analogs based on small molecules are rare and hard to design and thus represent a challenge for systems chemistry. In this work, we show that bistability can be designed from a simple non-equilibrium reaction cycle that is coupled to crystallization

SUBMITTER: Schnitter F 

PROVIDER: S-EPMC9122941 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature