A prospective matched case-control study on the genomic epidemiology of colistin-resistant Enterobacterales from Dutch patients.

ABSTRACT:

Background

Colistin is a last-resort treatment option for infections with multidrug-resistant Gram-negative bacteria. However, colistin resistance is increasing.

Methods

A six-month prospective matched case-control study was performed in which 22 Dutch laboratories with 32 associated hospitals participated. Laboratories were invited to send a maximum of five colistin-resistant Escherichia coli or Klebsiella pneumoniae (COLR-EK) isolates and five colistin-susceptible isolates (COLS-EK) to the reference laboratory, matched for patient location, material of origin and bacterial species. Epidemiological/clinical data were collected and included in the analysis. Characteristics of COLR-EK/COLS-EK isolates were compared using logistic regression with correction for v

SUBMITTER: Vendrik KEW 

PROVIDER: S-EPMC9122983 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature