Development and validation of radiologic scores for guiding individualized induction chemotherapy in T3N1M0 nasopharyngeal carcinoma.

ABSTRACT:

Objectives

We aimed to develop and validate radiologic scores from [¹⁸F]FDG PET/CT and MRI to guide individualized induction chemotherapy (IC) for patients with T3N1M0 nasopharyngeal carcinoma (NPC).

Methods

A total of 542 T3N1M0 patients who underwent pretreatment [¹⁸F]FDG PET/CT and MRI were enrolled in the training cohort. A total of 174 patients underwent biopsy of one or more cervical lymph nodes. Failure-free survival (FFS) was the primary endpoint. The radiologic score, which was calculated according to the number of risk factors from the multivariate model, was used for risk stratification. The survival difference of patients undergoing concurrent chemoradiotherapy (CCRT) with or without IC was then compared in risk-stratified subgroups. Another

SUBMITTER: Yang SS 

PROVIDER: S-EPMC9123027 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature