Risk of serious infections in multiple sclerosis patients by disease course and disability status: Results from a Swedish register-based study.

ABSTRACT:

Background and objectives

Serious infections are an emerging concern with increasing use of potent immunomodulation in multiple sclerosis (MS), but the extent to which MS disease features influence infectious susceptibility is poorly characterized. The objective of this study was to assess the associations of MS disease course and disability status with risk of serious infections.

Methods

A cohort of 8660 MS patients was individually matched on age, sex and region of residence with 86,600 people without MS from the general population using national registers in Sweden. The study period was from 1996 to 2012, with follow-up until December 31, 2014. The main outcomes were infection as the underlying or contributory cause of death or infection-related hospital admission identif

SUBMITTER: Brand JS 

PROVIDER: S-EPMC9123212 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature