Naturalization of the microbiota developmental trajectory of Cesarean-born neonates after vaginal seeding.

ABSTRACT:

Background

Early microbiota perturbations are associated with disorders that involve immunological underpinnings. Cesarean section (CS)-born babies show altered microbiota development in relation to babies born vaginally. Here we present the first statistically powered longitudinal study to determine the effect of restoring exposure to maternal vaginal fluids after CS birth.

Methods

Using 16S rRNA gene sequencing, we followed the microbial trajectories of multiple body sites in 177 babies over the first year of life; 98 were born vaginally, and 79 were born by CS, of whom 30 were swabbed with a maternal vaginal gauze right after birth.

Findings

Compositional tensor factorization analysis confirmed that microbiota trajectories of exposed CS-born babies aligned more clo

SUBMITTER: Song SJ 

PROVIDER: S-EPMC9123283 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature