Change in binding affinity with ACE2 receptor in beta, delta and omicron SARS CoV2 variants.

ABSTRACT:

Background

COVID-19 is still an important public health problem. After a pandemic, there is already new emerging mutant type of COVID-19. Starting from mutant with few mutations, the new mutant types with several mutations occur. Omicron variant is the new variant of concern that starts outbreak from Africa and might be the new problem worldwide.

Method

Pathogenesis may change as a result of molecular changes. An important possible effect of mutation is a change in binding affinity with receptor. Here, the authors performed a study to assess the effect of mutations of ACE2 receptor binding affinity in important COVID-19 variants, beta, delta and omicron variants.

Results

According to the analysis, change of binding affinity to receptor in each studied mutated variant

SUBMITTER: Mungmunpuntipantip R 

PROVIDER: S-EPMC9123474 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature