Modeling the Effects of Disease, Drug Properties, and Material on Drug Transport From Intraocular Lenses.

ABSTRACT:

Purpose

Surgically implanted intraocular lenses (IOLs) may be used as drug-delivery devices, but their effectiveness is not well defined. Computational fluid dynamics models were developed to investigate the capability of IOLs to release drugs at therapeutic concentrations.

Methods

Models were generated using COMSOL Multiphysics. Primary open-angle glaucoma (POAG) and wet age-related macular degeneration (AMD) were simulated by reducing aqueous vein and choroidal blood flow, respectively. Release of dexamethasone, ganciclovir, or dextran was studied using common IOL materials, polydimethylsiloxane (PDMS) and poly(2-hydroxyethyl methacrylate) (PHEMA).

Results

Drug clearance proceeds mainly through choroidal blood flow. When fully constricted, maximum concentration at t

SUBMITTER: Clasky DP 

PROVIDER: S-EPMC9123490 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature