Prevalence of Germline Findings Among Tumors From Cancer Types Lacking Hereditary Testing Guidelines.

ABSTRACT:

Importance

Germline testing guidelines are suggested for specific disease types or a family history of cancer, yet alterations are found in cancer types in which germline testing is not routinely indicated. The clinical role of identifying germline variants in these populations is valuable to patients and their at-risk relatives.

Objective

To evaluate the prevalence of germline findings in patients undergoing tumor/normal matched sequencing among cancer types lacking guidelines.

Design, setting, and participants

This retrospective cross-sectional study took place on August 18, 2021, and included data from deidentified records of patients tested, using the Tempus xT tumor/normal matched approach from November 2017 to August 2021. Records included in this study were fro

SUBMITTER: Yap TA 

PROVIDER: S-EPMC9123503 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature