Association between inflammatory molecules, nitric oxide metabolites and leg ulcers in individuals with sickle cell anemia.

ABSTRACT:

Introduction

Leg ulcers (LUs) are relatively common in patients with sickle cell anemia (SCA). The role of inflammation and nitric oxide (NO) pathways in the pathophysiology of the LU is not understood.

Objective

The aim of this study was to verify the association between inflammatory molecules and nitric oxide metabolites (NOx) and the occurrence of the LU in patients with SCA.

Method

It was a cross-sectional study on adult participants with SCA followed at Fundação Hemominas, a public blood center in Brazil. Eligible participants were recruited and included in one of two groups: Group 1, comprised of cases with SCA (Hb SS) and at least one LU at the time of inclusion in the study and Group 2, comprised of controls with SCA without a history of LU, matched by sex and

SUBMITTER: Belisario AR 

PROVIDER: S-EPMC9123559 | biostudies-literature | 2022 Apr-Jun

REPOSITORIES: biostudies-literature