Safety, activity, and pharmacokinetics of camrelizumab in advanced Asian melanoma patients: a phase I study.

ABSTRACT:

Background

Anti-programmed cell death receptor-1 (PD-1) monotherapy is the standard treatment for metastatic melanoma in current. Camrelizumab is a humanized IgG4 anti-PD-1 monoclonal antibody whose safety and efficacy have not been reported in advanced Asian melanoma patients.

Methods

This phase I study investigated the safety, activity, and pharmacokinetics of camrelizumab in Chinese patients with advanced melanoma. The study included two phases, the dose-escalation phase ("3 + 3" design at 60 mg, 200 mg, and 400 mg) and the dose-expansion phase.

Results

No dose-limiting toxicities were recorded over the dose-escalation phase, and the maximum tolerated dose was not reached. The most common treatment-related adverse events (TRAEs) in 36 patients were reactive cutaneo

SUBMITTER: Zhou L 

PROVIDER: S-EPMC9123656 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature