αvβ3-targeted sEVs for efficient intracellular delivery of proteins using MFG-E8.

ABSTRACT:

Background

Small extracellular vesicles (sEVs) are nanometer-sized membranous particles shed by many types of cells and can transfer a multitude of cargos between cells. Recent studies of sEVs have been focusing on their potential to be novel drug carriers due to natural composition and other promising characteristics. However, there are challenges in sEVs-based drug delivery, one of which is the inefficient loading of drugs into sEVs, especially for large biomolecules.

Results

In this study, we proposed a membrane-associated protein, milk fat globule-epidermal growth factor 8 protein (MFG-E8), to produce αvβ3-targeted sEVs with high delivery efficiency of interested protein. MFG-E8 is a secreted protein with NH2-terminal epidermal growth factor (EGF)-like domains, containin

SUBMITTER: Mai J 

PROVIDER: S-EPMC9123705 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature