Role of CDH23 as a prognostic biomarker and its relationship with immune infiltration in acute myeloid leukemia.

ABSTRACT:

Background

Cadherin-23 (CDH23) plays an important role in intercellular adhesion and is involved in the progression of several types of cancer. However, the biological functions and effect of CDH23 expression on the prognosis of patients with acute myeloid leukemia (AML) are unexplored. Herein, we aim to characterize the role and molecular functions of CDH23 in AML.

Methods

We downloaded the transcriptomic profiles and clinical data from the Cancer Genome Atlas and Beat AML trial. The expression level of CDH23 was assessed using Gene Expression Profiling Interactive Analysis (GEPIA). Kaplan-Meier survival analysis was used to assess prognostic value of CDH23. Correlation and biological function analyses were performed using LinkedOmics and GeneMANIA. Relationship of CDH23 wi

SUBMITTER: Yang J 

PROVIDER: S-EPMC9123811 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature