DRG microstimulation evokes postural responses in awake, standing felines.

ABSTRACT:

Objective

We have demonstrated previously that microstimulation in the dorsal root ganglia (DRG) can selectively evoke activity in primary afferent neurons in anesthetized cats. This study describes the results of experiments focused on characterizing the postural effects of DRG microstimulation in awake cats during quiet standing.

Approach

To understand the parameters of stimulation that can affect these postural shifts, we measured changes in ground reaction forces (GRF) while varying stimulation location and amplitude. Four animals were chronically implanted at the L6 and L7 DRG with penetrating multichannel microelectrode arrays. During each week of testing, we identified electrode channels that recruited primary afferent neurons with fast (80-120 m s^-1) and m

SUBMITTER: King KW 

PROVIDER: S-EPMC9124048 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature