Marine-Derived Stichloroside C2 Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis through the Mitogen-Activated Protein Kinase Signalling Pathway in Triple-Negative Breast Cancer Cells.

ABSTRACT:

Background

Triterpenoid saponins from sea cucumbers exhibit significant antitumour, antifungal, and antibacterial activities. However, the associated molecular mechanisms have yet to be elucidated. In this study, we screened and explored the antitumour activity and underlying mechanisms of triterpenoid saponins isolated from Thelenota ananas.

Methods

We isolated and purified sea cucumber saponins, determined their chemical structures, and confirmed their function in vitro. We also screened and explored the antitumour activity and underlying mechanisms of triterpenoid saponins isolated from Thelenota ananas.

Results

Four saponins were discovered from sea cucumber Thelenota ananas collected from the South China Sea. We found that stichlorosid

SUBMITTER: Cui C 

PROVIDER: S-EPMC9124082 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature