Brain Network Changes in Lumbar Disc Herniation Induced Chronic Nerve Roots Compression Syndromes.

ABSTRACT: Lumbar disc herniation (LDH) induced nerve compression syndromes have been a prevalent problem with complex neural mechanisms. Changes in distributed brain areas are involved in the occurrence and persistence of syndromes. The present study aimed to investigate the changes of brain functional network in LDH patients with chronic sciatica using graph theory analysis. A total of thirty LDH adults presenting L4 and/or L5 root (s) compression syndromes (LDH group) and thirty age-, sex-, BMI- and education-matched healthy control (HC group) were recruited for functional MRI scan. Whole-brain functional network was constructed for each participant using Pearson's correlation. Global and nodal properties were calculated and compared between two groups, including small-worldness index, clustering

SUBMITTER: Zhang YP 

PROVIDER: S-EPMC9124092 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature