FLG Is a Potential Biomarker of Prognosis and Immunotherapy in Skin Cutaneous Melanoma.

ABSTRACT:

Background

Skin cutaneous melanoma is one of most aggressive type of cancers worldwide. Therefore, the identification of SKCM biomarkers is of great importance. FLG gene is one of the genes that encode proteins involved in epidermal formation. This was the first time to study the role of FLG in the prognosis and immune infiltrates of skin cutaneous melanoma.

Methods

We downloaded the somatic mutation data of 471 SKCM patients from the Cancer Genome Atlas (TCGA) database and analyzed the mutation profiles with "MafTools" package. The expression of FLG and the overall survival in SKCM were analyzed by GEPIA. Additionally, univariate and multivariate Cox analyses were used to compare several clinical features with survival rates. We used TIMER to investigate FLG expression and

SUBMITTER: Wu S 

PROVIDER: S-EPMC9124147 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature