Stress-induced despair behavior develops independently of the Ahr-RORγt axis in CD4 + cells.

ABSTRACT: Current treatments for major depressive disorder are limited to neuropharmacological approaches and are ineffective for large numbers of patients. Recently, alternative means have been explored to understand the etiology of depression. Specifically, changes in the microbiome and immune system have been observed in both clinical settings and in mouse models. As such, microbial supplements and probiotics have become a target for potential therapeutics. A current hypothesis for the mechanism of action of these supplements is via the aryl hydrocarbon receptor's (Ahr) modulation of the T helper 17 cell (Th17) and T regulatory cell axis. As inflammatory RORγt + CD4 + Th17 T cells and their primary cytokine IL-17 have been implicated in the development of stress-induced depression, the connection

SUBMITTER: Rivet-Noor CR 

PROVIDER: S-EPMC9124178 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature