The Role of Metabolic Factors and Steatosis in Treatment-Naive Patients with Chronic Hepatitis B and Normal Alanine Aminotransferase.

ABSTRACT:

Introduction

We aimed to elucidate the impact of metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD) on treatment-naïve patients with chronic hepatitis B (CHB) and normal alanine aminotransferase (ALT).

Methods

We analyzed the clinical characteristics of a cross-sectional cohort of treatment-naïve patients with CHB and ALT in the upper limit of normal (ULN) from October 2018 to July 2021. ALT ≤ 0.5 ULN was stratified as low-normal ALT (LNALT) and 0.5 ULN < ALT ≤ ULN as high-normal ALT (HNALT). Transient elastography (TE) was used to evaluate liver steatosis and fibrosis.

Results

Among 733 patients with CHB enrolled, 23.1% of them had MS, 37.2% of them had NAFLD, and 5.9% of them had significant fibrosis. The proportions of patients with MS, steatosis,

SUBMITTER: Diao Y 

PROVIDER: S-EPMC9124274 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature