Role of upregulation of the K_ATP channel subunit SUR1 in dopaminergic neuron degeneration in Parkinson's disease.

ABSTRACT: Accumulating evidence suggests that ATP-sensitive potassium (K_ATP ) channels play an important role in the selective degeneration of dopaminergic neurons in the substantia nigra (SN). Furthermore, the expression of the K_ATP channel subunit sulfonylurea receptor 1 (SUR1) is upregulated in the remaining nigral dopaminergic neurons in Parkinson's disease (PD). However, the mechanism underlying this selective upregulation of the SUR1 subunit and its subsequent roles in PD progression are largely unknown. In 3-, 6-, and 9-month-old A53T α-synuclein transgenic (α-SynA53T^+/+ ) mice, only the SUR1 subunit and not SUR2B or Kir6.2 was upregulated, accompanied by neuronal damage. Moreover, the occurrence of burst firing in dopaminergic neurons was increased with the u

SUBMITTER: Liu M 

PROVIDER: S-EPMC9124303 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature