Semimechanistic models to relate noxious stimulation, movement, and pupillary dilation responses in the presence of opioids.

ABSTRACT: Intraoperative targeting of the analgesic effect still lacks an optimal solution. Opioids are currently the main drug used to achieve antinociception, and although underdosing can lead to an increased stress response, overdose can also lead to undesirable adverse effects. To better understand how to achieve the optimal analgesic effect of opioids, we studied the influence of remifentanil on the pupillary reflex dilation (PRD) and its relationship with the reflex movement response to a standardized noxious stimulus. The main objective was to generate population pharmacodynamic models relating remifentanil predicted concentrations to movement and to pupillary dilation during general anesthesia. A total of 78 patients undergoing gynecological surgery under general anesthesia were recruited fo

SUBMITTER: Marco-Arino N 

PROVIDER: S-EPMC9124350 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature